A secreted MMP is required for reepithelialization during wound healing

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A secreted MMP is required for reepithelialization during wound healing

Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaster, whose genome encodes only two MMPs-one secreted type (Mmp1) and one membran...

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ژورنال

عنوان ژورنال: Molecular Biology of the Cell

سال: 2012

ISSN: 1059-1524,1939-4586

DOI: 10.1091/mbc.e11-09-0745